Ibuprofen Information

Ibuprofen is one of the most used in the so-called “acid” for the pain is in addition to , and acetylsalicylic acid. Thanks to its acidic nature of acts in contrast to substances such as Paracetamol, or dipyrone, not only against suffering but also against , because these do not penetrate so well in the inflamed and this acidified tissue.

Effect of Ibuprofen

Ibuprofen is used to quench mild to moderate pain and to stop inflammation, stop – for example, in the case of rheumatic diseases, which respond to inflammation by painful Joint. In addition, Ibuprofen has antipyretic properties, is used for this purpose but is hardly therapeutic.

Ibuprofen belongs to the class of non-steroidal anti-inflammatory Drugs (NSAIDs), in contrast to, for example, cortisone. The active ingredient Ibuprofen is inhibitors in addition, a representative of the non-opioid analgesics, belongs to the group of (unlike opioids) addiction triggering and worldwide commonly used Cyclooxygenase.

The effect of Ibuprofen is due to the fact that Cyclooxygenase is disabled. Therefore, the so-called prostaglandins, which promote inflammations, pain, triggering, and fever increase are simulated, only reduced.

Areas of application of Ibuprofen

Particularly often used and originally developed Ibuprofen for the treatment of rheumatic disorders tables in the joint. It helps to relieve the inflammation, swelling and pain in osteoarthritis, , and gout. In a lower dose of Ibuprofen helps also good against headaches and migraines, and dental pain, or menstrual pain.

Also used Ibuprofen comes cracks in the case of muscle pain and sports injuries such as pulled muscles and ligaments, alternatively, Diclofenac helps. Further areas of application for pain treatment in acute otitis media, tonsillitis, or sun burn.

Ibuprofen: Dosage

Ibuprofen is sold in different dosage forms. It is available as a tablet, capsule, suppository, juice, granules or ointment. The drug is available in different dosages in the trade, the low are freely available in pharmacies. Ibuprofen in doses above 400mg are prescription-only medicines.

The range of effect of Ibuprofen depends on the dose: Lower doses of between 200 and 800mg in adults are primarily analgesic and antipyretic. Only at higher dosages up to 2400mg daily the inflammation is inhibitory effect. The collected funds will remain about two to three hours in the same concentration in the blood, then the effect decreases. The majority of the degradation products are excreted via the kidney, partly by the liver.

In contrast to the relatives of acetylsalicylic acid can be used after consulting a doctor Ibuprofen in children. A Treatment is, for example, in preterm infants. In order to support the immature heart, helps to close the often persistent Ductus arteriosus, a connection between the venous and arterial System, with the help of Ibuprofen.

Ibuprofen: Side Effects

Often it comes in the case of Ibuprofen to side effects such as stomach pain, Nausea, and diarrhea. Rarely, dizziness, headache, and a reversible loss of visual acuity occur.

As by the relatives of Cyclooxygenase inhibitors acetylsalicylic acid and Diclofenac, can also lead to the frequent use of Ibuprofen gastrointestinal bleeding to a Gastric perforation. Because the inhibition of Cyclooxygenase is not only reduces the production of unwanted inflammatory prostaglandins. Also, the prostaglandins, which protect the normally the stomach, which makes the stomach very sensitive to the contained digestive enzymes and stomach acid.

Due to its longer duration of Ibuprofen should be conducted therapy only in combination with a gastric protection. Are recommended this medication, which reduce the production of stomach acid, for example, a proton pump inhibitor such as omeprazole or pantoprazole. It also helps to protect the stomach when taking these drugs sober.

Of a parallel therapy with steroidal pain medications such as cortisone is not recommended, because this would increase the risk of bleeding. Caution is advised in patients with known inflammatory stomach-intestinal diseases such as ulcerative Colitis or Crohn’s disease, because this can taking Ibuprofen cause an acute relapse of these diseases.

Ibuprofen: Interactions

In addition, Ibuprofen has platelet inhibitory effects on the storage of blood, similar to the effect of acetylsalicylic acid. Therefore, an increased bleeding risk. The concomitant use of other anticoagulants, such as marcumar®, therefore, can be of concern.

Paradoxically, however, the effect of other platelet inhibitors such as acetylsalicylic acid when co-administered due to competition at the same Receptor. This can lead to an increase of thrombi and emboli. Because of the unpredictable effect on your blood clotting, you should inform the doctor before surgery to make sure prior to taking painkillers.

Ibuprofen in pregnancy

Also problems with unwanted extensions of a pregnancy in the context of the Prostaglandin intake, it is reported that Some prostaglandins act labor-promoting. These are formed is reduced, accordingly, the blow until too late.

The doctrine, accordingly, the treatment of rheumatoid Arthritis seems to be in a low dosage to 600mg a day, even during pregnancy and lactation is safe. Other Doctors see pregnancy as a clear contraindication for a therapy with Ibuprofen. In the respective individual case is therefore advised strongly to keep time with the doctor.

Ibuprofen: Contraindications

Less commonly, it comes to so-called “Aspirin Asthma”, which can also occur at the time of taking the painkillers Ibuprofen and Diclofenac 100mg. The fact that reduced prostaglandins to be formed, converts the body to the starting substance in leukotrienes. This can trigger irritation of the throat and constrict the lungs.

Also patients who have stressed kidneys, you need to be when taking Ibuprofen and other cyclooxygenase inhibitors carefully because the renal vessels constrict when fewer prostaglandins to be formed. This can reduce an already low kidney function even further, and in the worst case, to the Dialysis. The ingestion of Ibuprofen in the case of existing renal disease must be monitored carefully.

Similar to the case of liver disease, as a part of the drug is metabolized by the liver. It is therefore not recommended of alcohol consumption during treatment, since this strain on the liver. Regular checks the kidney and liver values in the case of long-term intake of Ibuprofen are therefore important.

In the case of concurrent lithium therapy, it is important to control the plasma levels of this antidepressant to be particularly careful, as lithium excretion is reduced in the kidneys due to the Ibuprofen-taking. The same is true for therapy with the antiepileptic drug Phenytoin, this is reduced in the presence of Ibuprofen slows down.

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