Duloxetine is an antidepressant and works by increasing noradrenaline and serotonin levels of the drive-enhancing and mood-elevating. DULOXETINE is used primarily in the treatment of depression. Another major area of application of stress incontinence in women, since the active ingredient strengthens the bladder and pelvic floor muscles. Learn more about the effects, side effects and dosage of DULOXETINE.
Further areas of application of Duloxetine
Duloxetine is also used in diabetic polyneuropathy. Due to its pain-relieving effect, it helps in the Diabetes-induced nerve neuropathy) pain (.
In the US, DULOXETINE is also approved for the treatment of fibromyalgia, a muscle pain syndrome. In Germany, the use in this indication by the European medicines has been rejected by Agency (EMA) in 2008.
DULOXETINE dosing and discontinuation
How many capsules of DULOXETINE daily should take, you must choose the treating physician. As a rule, this will be a psychiatric specialist. The amount of the dose depends on the age, sex, height, weight and also the Smoking status.
A typical starting dose is 60 mg once daily, followed by a continuous increase up to a maintenance dose of 120 mg.
It is important that the drug is not short-hand to sell, but to taper, otherwise serious side effects threatening.
Side effects of DULOXETINE
Among the most common side effects of Duloxetine:
- Diarrhea and constipation
- a dry mouth
- Loss of appetite
In addition, visual disturbances, a Tremor, and sleep disturbances. Due to the increased level of noradrenaline, it can continue to sweat and hot flashes, blood increases pressure, urinary retention and erectile dysfunction.
A critical side effect caused by the initial drive to increase the drug. As this effect sets in even before the mood-lightening effect, try the risk of suicide in the first two weeks after start of therapy, which is why you should be taken care of in this period closely by a specialist.
Interactions with DULOXETINE
Combined Duloxetine with other antidepressants, which also lead to a level increase of Serotonin should be. It is the life-threatening Serotonin syndrome, which is manifested by tachycardia, fever and Nausea felt threatened otherwise.
To avoid a simultaneous intake of CNS depressant substances such as benzodiazepines, opiates and alcohol is also.
Contra-indications of the active substance
The following contraindications must be observed when taking DULOXETINE:
- MAO inhibitors such as Selegelin, or Tranylcypromine
- Serotonergic drugs, for example, venlafaxine, fluoxetine, Citalopram
- Certain antibiotics such as Ciprofloxacin, or enoxacine
- St. John’s wort
- Liver and kidney function disorders
- An Allergy to the active substance DULOXETINE
- Children under the age of 18 years
- Uncontrolled High Blood Pressure
In pregnancy and lactation is not an absolute is a contra-indication, but also no recommendation for the taking, since there are no studies of DULOXETINE in these circumstances.
Instructions on taking Duloxetine
Taking the DULOXETINE capsules should be independent of the meals. Regarding the duration of intake is important to note that DULOXETINE should be taken for at least six months, to be able to an effect to be observed.
DULOXETINE is a so-called “Serotonin-norepinephrine-Reuptake-Inhibitor” (SNRI). The group of drugs, the SNRIs, including venlafaxine, are in the Central nervous system effectively. Here a complex Interplay of various hormones and messenger finds substances (neurotransmitters instead of transmitters). An important role of the neurotransmitters Serotonin and norepinephrine play.
Serotonin is everywhere in the body and has various functions. In the brain, it is, among other things, for the happiness feel responsible. Norepinephrine is affected, a stress hormone, which blood pressure and pulse. To the nerve cells, it has a drive-enhancing and activating effect.
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Mechanism of action of Duloxetine
In the nerve cells of Serotonin and norepinephrine in the so-called “synaptic cleft are distributed”, which communicate between two nerve cells. By attaching to the receptors on the following nerve cell, the neurotransmitters exert their effect.
Duloxetine prevents the reuptake of the two neurotransmitters back to the origin cell, and thus ensures a persistently high concentration, and a sweeping effect. Due to the increase Concentration of norepinephrine, the pain-relieving nerve pathways in the spinal cord are stimulated, so that activates the body’s own pain relief.