Nowadays, more and more people are feeling depressed, burnt out and hopeless – depression have become a national disease. The antidepressant venlafaxine helps against the above-mentioned symptoms, by acting mood-lifting. Venlafaxine, is especially suitable for people whose Depression and anxiety is accompanied, because the active ingredient is also used in the treatment of panic attacks and other anxiety. Just as with other antidepressants it may also occur when taking venlafaxine to side effects. A particularly strong side-effects may occur upon Discontinuation of venlafaxine.
In this way, venlafaxine acts
Venlafaxine, like DULOXETINE, the Serotonin-norepinephrine reuptake inhibitors (SNRIs). Thus, these antidepressants are different from drugs such as fluoxetine or Citalopram, which belong to the group of selective Serotonin reuptake inhibitors (SSRIs).
In contrast to them, venlafaxine inhibits not only the re-uptake of Serotonin but also of norepinephrine and dopamine. The re-uptake of norepinephrine and dopamine, however, is inhibited only when venlafaxine is taken in a higher dosage. A reduced content of the substances Serotonin, Noradrenalin and dopamine is considered to be triggers of depression.
Due to the blocking effect of venlafaxine, the materials can remain longer in the synaptic gap and their concentration increases. This can result in depressive people to a brightening of the mood. In addition, the drug is for the treatment of anxiety disorders is helpful, because it triggers anxiety. The correct dosage of venlafaxine should always be with the doctor agreed.
Side effects of venlafaxine
Many of those Affected suffer in the first days and weeks after you start taking an antidepressant, under more or less strong side effects. In the case of venlafaxine, the experiences are so far quite positive. Among the most common side effects of venlafaxine are Nausea and headaches.
Often it comes in addition to blockages, nervousness and insomnia, erectile dysfunction, and loss of appetite and weight loss. Occasionally venlafaxine can also lead to weight gain. From time to time, it can also cause skin heart rhythm disturbances, bleeding, or hair loss. Rare side effects such as seizures or hot flashes are.
In the current studies, it was demonstrated, moreover, that by a long – term intake of certain substances from the group of SSRI or SNRI, the work of the knochenab and structure of cells can be impeded. This may increasingly lead to bone fractures and an increased risk of osteoporosis. For active substances for which this side effect in the Individual, but it is still unclear. For a complete list of side effects of venlafaxine, please refer to the package insert of each drug.
Increased risk of suicide as a result of
Similar to other antidepressants such as fluoxetine and the suicide risk is even with taking venlafaxine during the first weeks of therapy increases. Even after a change of dosage, the risk of suicide may increase. Patients should self-monitor during this period strictly, but also from friends, Relatives and the treating physician are monitored. The highest risk of suicide is observed in adolescents and young adults under the age of 30.
From a medical point of view, the increased suicide is the result of a danger on the drive-enhancing effect of venlafaxine. Especially for patients who have ever thought about suicide, by the action of the antidepressant, rather, ready your plans to actually implement.
Side effects upon Discontinuation of venlafaxine
Although the side effects from a fall while taking mostly rather low, but the Discontinuation of venlafaxine can be unpleasant experience. To avoid this, if possible, venlafaxine should not be stopped suddenly, but the dose of the antidepressant can be gradually reduced. Nevertheless, when you set it down often to symptoms (SSRI discontinuation syndrome).
What are the symptoms how strong is occur is by the duration of treatment and the dosage of the active ingredient, and individually from Patient to Patient is different.
Among the most common side effects after the Discontinuation of venlafaxine:
- Fatigue and dizziness,
- Insomnia and other sleep disorders,
- Nervousness and anxiety,
- Loss of appetite,
- Tremble as well as
- Diarrhea and vomiting
In General, the discomfort should subside within two weeks, some of the listed side effects are but two or three months after Weaning.
The antidepressant, venlafaxine should not be used if Hypersensitivity to the active substance. Also, the active ingredient should not be used together with monoamine oxidase inhibitors (MAO inhibitors) also have an anti-depressive effect. Is switched from one antidepressant to the other, should lie between a minimum of two-week drug-free Phase.
In addition, venlafaxine may not be taken together with other substances that also have a serotonergic effect. All of the SSRIs include drugs as well as Lithium, St. John’s wort, and triptans. In combination of venlafaxine with these drugs is the so-called Serotonin disorder can occur, which can end in the worst case, fatal.
Interactions with venlafaxine
Patients in whom a disease of the kidneys or liver, before taking venlafaxine by the attending doctor for advice. The same is true for patients receiving electro-shock treatments, or suffering from seizures. Here account must be set up to Use by the attending physician in each case, a cost -.
While taking is also recommended regular monitoring of blood pressure, since venlafaxine, depending on the administered dose can lead to an increase in blood pressure. Note, moreover, that the responsiveness is set by the active substance. This effect of venlafaxine is associated with alcohol.
During pregnancy, venlafaxine should be used only in particularly urgent cases and with a doctor explicitly discussed. Because the active ingredient may lead to increased blood pressure, breathing difficulties or vomiting in the newborn. Also during lactation you should not use venlafaxine, since the active ingredient is excreted in breast milk. The taking is absolutely necessary, should not be breastfed the child.
In the case of children under the age of 18 years, side effects on the development are not yet fully explored, as is generally recognised, however, that by the ingestion of venlafaxine, the aggressiveness of the children is on the rise.