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Amitriptyline is a so-called re-uptake inhibitors: This medicine prevents the re-uptake of neurotransmitters, substances that transmit the signals between nerve cells. Because neurotransmitters are always used again by the nerve cells (re-recording), there can be a lack of these ambassadors. As a result, the signal transmission between the nerve cells of pain, complaints of pain, such as nerve, migraine and depression may arise. Amitriptyline raises the lack of neurotransmitters, causing symptoms can be alleviated.