Doxepin is a drug that belongs to the group of drugs called tricyclic antidepressants. It is mainly used for the treatment of depression, but States, but also in fear and in addiction therapy can be used. By taking side effects like fatigue, dizziness, itching, and weight can occur increase. Learn more here to effect, side effects and dosage of Doxepin.
Doxepin belongs to the group of drugs called tricyclic antidepressants that includes drugs such as amitriptyline or Opipramol. The active ingredient is not only used to treat depression, but can also help with anxiety and sleep disorders. In addition, it comes in the addiction treatment, especially with opiate-dependent people.
Doxepin has a damping effect and lifts the spirits. While the dampening effect kicks in usually within an hour after taking it, the brightening of the mood, often after two to three weeks. Therefore, especially in patients with suicidal thoughts at the beginning of the intake must be closely monitored. With regard to the damping effect must be noted that this may decrease in the case of a long-term intake of the antidepressant.
Effect of Doxepin
Doxepin increases in the brain concentration of Serotonin and norepinephrine by inhibiting the reuptake of the chemical messengers in your memory. In addition, the drug blocks the histamine receptors and destroys the effectiveness of the Gewebshormons histamine. Similarly, Doxepin reduces the effectiveness of the neurotransmitter acetylcholine. This can manifest itself in a lower blood pressure and a slower heartbeat.
Side effects of Doxepin
At the beginning of the treatment with Doxepin side effects such as fatigue, drowsiness, dry mouth, dizziness, Tremor, drop in blood pressure, heart rhythm disturbances, constipation, and weight gain.
Later allergic skin reactions and itching, sexual disorders, problems with urination, thirst and restlessness is a common side effects. Occasionally it can be behavior in addition to conduction problems, circulatory problems, Urinary, abnormal sensations in the tissues, such as tingling, ringing in the ears and increased Dreaming.
Among the very rare side effects of Doxepin an enlargement of the Breasts (in both men and women), changes in the levels of blood sugar, loss of hair, changes in the blood picture, heart rhythm disorders, as well as a drug-dependent Hepatitis finally.
Doxepin dosing correctly
The active substance Doxepin is available in various dosage forms, including tablets, Dragees, capsules, drops or solutions for Injection. The exact dosage will be determined individually by the attending physician. Please understand the following dosage information only as General guidelines.
Doxepin is used to treat depression, is prescribed at the beginning of therapy often only a low dose. This is then increased gradually until the smallest effective dose is determined. Usually, it is started with 50 milligrams, the dose can then be increased relatively quickly up to 150 milligrams. In the case of a stationary stay in hospital of up to 300 milligrams.
In the case of older persons at increased risk for the Occurrence of side effects. You should take the antidepressant, so it is a low dose. This is also useful because it can come at you by taking you to States of Confusion.
Overdose is dangerous
In the case of an Overdose of Doxepin, you should consult a doctor immediately, because Overdose can have potentially serious side effects. Depending on how high the dose was, it can come to disturbances of the cardiovascular system and Central nervous system. Thus, confusion and seizures, in severe cases, coma and respiratory occur to a standstill.
To avoid an Overdose, you should not make up for a forgotten dose. Continue taking instead, as usual, to the next time.
Treatment with Doxepin and should be terminated – especially if the active ingredient was in the long term and in high doses taken – never abruptly. Otherwise, side effects such as Nausea, vomiting, restlessness, and sleep disturbances. You will always discuss with your doctor how to proceed with the Discontinuation of the drug at the best. As a rule of thumb, the dose should be reduced each week by more than half.
A Variety Of Interactions
To be taken concurrently with other antidepressants or drugs against Parkinson’s disease, can increase effects and side effects of Doxepin. In addition, the dampening effect by neuroleptics, sedative antihistamines, anticonvulsants, pain, sleep, and sedatives, as well as the drug cimetidine may be increased. Also by alcohol to an amplification or change in the Doxepin can occur effect.
Medicines that reduce the potassium levels, the removal of Doxepin in the liver to block or prolong the QT interval, should also not be taken simultaneously with the antidepressant. The same is true for medications for high blood pressure (clonidine, reserpine). Doxepin is used concurrently with H1-antihistamines, antipsychotic drugs, antimalarial drugs, antibiotics, antipsychotic, or antiarrhythmic drugs, can be enhanced by the fact of existing heart rhythm disorders.
Interactions with MAO inhibitors
So-called MAO-inhibitors that are also used to treat depression, may not normally be used simultaneously with Doxepin. In General, the therapy should be stopped at least two weeks prior to the start of treatment with Doxepin. Otherwise, it can cause serious side effects such as seizures, loss of consciousness, high fever and clouding of consciousness.
In the case of depression, which are difficult to treat, in individual cases, the additional administration of MAO-inhibitors. Then the Patient must be observed carefully by the treating physician. In addition, the dose of the MAO may be increased inhibitors only slowly.
Doxepin should not be used if Hypersensitivity to the active substance. In addition, the antidepressant must not be taken:
- a paralysis-related intestinal obstruction
- acute urinary retention
- a poisoning with sleep and painkillers as well as alcohol and psychotropic drugs
- acute Delirium
- an enlargement of the prostate with residual urine formation
- narrow-angle glaucoma
Only after a careful Benefit-risk assessment, you should take the drug in case of severe liver damage, enlargement of the prostate without urinary retention, slowed heart rate, heart diseases such as long QT syndrome, potassium deficiency, disorders of blood formation, or increased convulsive readiness.
In General, the use of Doxepin requires regular medical control. Blood pressure, ECG, liver function and blood picture must be checked. Be found to be deviating from the Norm values, the treatment only continued if the Patient is checked in short intervals.
Pregnancy and lactation
As for the application of Doxepin during pregnancy so far, not enough experience, should be taken with the antidepressant only when it is absolutely necessary. In advance should be made Use of by the physician, a careful risk assessment. Because taking can occur in the newborn withdrawal symptoms. Possibly also the risk for a malformation increases.
During lactation Doxepin should not be taken, as the active ingredient can pass into breast milk. This can occur in the infant may be side effects. A treatment is absolutely necessary, should be discontinued.
Children under the age of twelve should not take the antidepressant just like breastfeeding mothers. Because there are no studies of the effect of a long-term application growth, maturation, and cognitive development of children and young people. Also in the case of young people up to 18 years of Doxepin is not used in the rule, since the active ingredient has Use you is probably not therapeutic.