Sertraline For Depression


The active ingredient is used to treat as well as anxiety disorders, obsessive-compulsive disorder and post-traumatic used tables load disturbances. The antidepressant medication exerts its effect in the brain by increasing the concentration of the neurotransmitter Serotonin. As with other antidepressants, sertraline side effects: During treatment, it can lead to dizziness, headaches and gastrointestinal problems. Here you can learn more about possible side effects, as well as the effect and dosage of the active ingredient.

Effect of sertraline

Sertraline belongs to exactly like Citalopram and fluoxetine, the selective Serotonin reuptake inhibitors (SSRIs). This group inhibits in the brain, the recording of the neurotransmitter Serotonin in the cells, so that the concentration in the synaptic cleft increases. As a result, the Depression is counteracted, because depressions are probably caused by a lack of the messengers, noradrenaline and Serotonin, substances in the brain.

Sertraline is used to treat depression, it acts from the first intake drive enhancing. To the mood-enhancing uses at the end of action of the antidepressant, it may take some days. The active ingredient, however, is used not only for the treatment of depression, but also as a preventive measure: By the intake should be ensured that it will not again depressive phases occur.

Side effects of sertraline

Sertraline has a number of side effects – such as these occur, especially of the ingested dose-dependent. Some of the side effects disappear with time or, better, at least in the course of treatment. As a General rule, the antidepressant has fewer side effects than other SSRIs.

Among the most common side effects are dizziness, sleeplessness, Tremors, drowsiness, sexual disturbances, and gastrointestinal problems such as Nausea and diarrhea. Often fatigue, loss of appetite also occur, skin rash, headache, ringing in the ears, vomiting, constipation, , and heart palpitations.

Occasionally it can be by the intake of the active ingredient to side effects such as weight gain, fever, skin bleeding, liver disorders, hair loss, and heart rhythm disorders Rarely also blood platelet deficiency, underactive thyroid, seizures, and urine may occur behavior.

For a complete list of side effects of sertraline you throw leaflet please take a look in the pack.

Serotonin syndrome, a dangerous side effect

In the case of an Overdose of sertraline, or of the simultaneous intake of other drugs that affect Serotonin levels, can occur this life-threatening Serotonin syndrome. By the excessively high Serotonin levels in the brain can cause symptoms such as Nausea, diarrhea, sweating, confusion, and seizures, or even coma. The Serotonin syndrome is life-threatening and must be treated therefore on the intensive care unit.

Sertraline discontinuation

If you want to stop treatment with sertraline, you must also count on the side effects. Whether and to what extent they occur depends on both the dosage and duration of treatment also of the speed of dose reduction. Therefore, you should stop the drug and never abruptly, but the treatment is always slow to finish. Discuss with your doctor how you should the Discontinuation of the drug at the best course of action.

On Discontinuation of sertraline, among other side effects, such as headaches, Nausea, vomiting, sleep disturbances, dizziness, and anxiety can occur. In General, the complaints within two weeks from the blades, sometimes it can take between two and three months until all side effects are disappeared.


The optimal dosage of sertraline you should always discuss with your doctor. Depending on the diagnosis, the dosage of the active ingredient can be very different. If not otherwise prescribed, in adults the following doses:

  • Depression and obsessive-compulsive disorder: 50 mg Once daily sertraline (maximum dose: 200 mg)
  • Panic disorders, anxiety disorders and post-traumatic stress disorder: Initially once a day 25 sertraline, the dose may be increased after one week to 50 mg (maximum dose: 200 mg)

Sertraline should be taken once daily in the morning or in the evening. Due to the mood-enhancing effect, we recommend taking it in the Morning. The active ingredient can be taken either with or between meals.


Just like other drugs, there are also, in the case of sertraline, a number of contraindications. Thus, the active ingredient should not be used, for example, if there is a Hypersensitivity to the antidepressant.

Similarly, sertraline should not be used if treatment with MAO-inhibitors. As a General rule, between treatment with MAOIs and treatment with sertraline for at least a period of 14 days. Otherwise, the life-threatening Serotonin can occur syndrome. In addition to MAO inhibitors, sertraline may also be not together with Pimozide, and Disulfiram taken.

Possible Interactions

While you are taking sertraline may lead to interactions with certain other medications. This applies in particular for the following active ingredients:

  • Drugs, which contain the amino acid Tryptophan
  • Herbal medicines containing St. John’s wort
  • Drugs for the treatment of severe pain
  • Diuretics
  • Drugs for the treatment of migraine
  • Drugs for the treatment of ulcers and excess stomach acid

If you are taking any of these medicines, you should inform your doctor before starting treatment not necessarily about it. This also applies if you are already being treated with another antidepressant.

Increased risk of suicide at the beginning of the treatment

Under certain conditions, the intake of sertraline may be carried out only with special caution. This is, for example, in patients with epilepsy or other seizure disorders. Also in the past, a schizophrenia or a manic-was depressive disorder, need to be monitored during the treatment.

People who suffer from liver disease, Diabetes or a bleeding disorder, you should inform your doctor before treatment about your disease. The same is true for people who have a low sodium level and are taking blood-thinning or blood pressure-lowering drugs.

By the intake of sertraline may occur at the beginning of the treatment to an increased risk of suicide. Of this side effect in particular, young adults are affected under the age of 25. If you have had in the past of Self – harm or thoughts of suicide, you should talk about it before taking with the attending physician. The thoughts while you are taking, you should consult your doctor or a trusted person to speak.

Sertraline and alcohol

During treatment with sertraline, you should avoid the consumption of alcohol. Although could be found in studies by the mixture of the two substances, yet not have a negative impact on the physical and mental abilities. Nevertheless, it is recommended – as is the case with many other drugs, too – to drink during the treatment, no alcohol.

Pregnancy and lactation

During pregnancy and lactation is not advisable by the intake of sertraline. The active ingredient may only be used in case of absolute necessity and after consultation with a doctor. Because by taking it can lead to malformations in the unborn child, as well as an increased in the lungs in the newborn.

In lactating women, the antidepressants, in small amounts excreted in breast milk. Therefore, the drug should not be taken during lactation. Although to date no impairments have been observed on the infant, however, this can not be excluded.

Children and young people should also be only in exceptional cases and after a careful cost-Benefit analysis with sertraline-treated. You can be triggered by taking a more aggressive behavior, as well as an increased risk of suicide. Moreover, the findings about possible consequences on the development of the child are not enough.

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